A reagent-free oxidative cyclization approach to indolizine derivatives from α-picoline derivatives and nitroolefins

Chem Asian J. 2014 Aug;9(8):2068-71. doi: 10.1002/asia.201402096. Epub 2014 Apr 29.

Abstract

A reagent-free oxidative cyclization between α-picoline derivatives and nitroolefins has been developed. This approach, in which the nitro group acts as an internal oxidant, provides an extremely simple, efficient, and atom-economic way to construct heteroaromatic indolizine derivatives.

Keywords: green chemistry; indolizines; nitroolefins; oxidative cyclization; reagent-free; synthetic methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Cyclization
  • Indicators and Reagents / chemistry
  • Indolizines / chemistry*
  • Mass Spectrometry
  • Oxidation-Reduction
  • Picolines / chemistry*

Substances

  • Alkenes
  • Indicators and Reagents
  • Indolizines
  • Picolines
  • indolizine