The revealed correlation of blood pressure variation in the females who had used hormonal contraceptives and certain features of their cardiovascular histories were used to define the group of risk for borderline arterial hypertension during the intake of Ovidon or Non-Ovlon and to develop the criteria for differentiated choice of estrogen-gestagen drugs.
PIP: Potential adverse effects of estrogen-gestagen contraceptive agents on blood pressure were studied in 220 fertile women (19 to 45 years old) throughout 2152 menstrual cycles. The contraceptive agents used were ovidon, non-ovlon, rigevidon and triquilar. Blood pressure was measured prior to administration of contraceptive agents, after 3, 6, 9 and 12 months of administration, and 1 month after termination of administration of estrogen-gestagen contraceptives. Evaluation of the cardio-vascular status indicated that of 220 women 212 had various risk factors for elevated blood pressure: 28 had excessive body weight, 14 were older than 35 years, 21 had a history of complicated pregnancy and labor, 2 had neurocirculatory dystonia, 54 had family history of cardio- vascular diseases, 70 smoked at least 20 cigarettes; more than on half of women (163) complained of headache of various severity. Each risk factor was assigned a rank of 1 (weak), 2 (moderate), or 3 (strong). All contraceptive agents tested had an effect on blood pressure. The most pronounced elevation of blood pressure was observed after administration of ovidon: statistically significant increase of the systolic blood pressure was observed after 3-month administration and after 1 year this parameter exceeded the initial values by 6-7 mm Hg. During the use of non-ovlon, significant increase of the systolic blood pressure was first observed later, after 6 months, and 1 year later it exceeded the initial values only by 3-4 mm Hg. Significant increase of the diastolic pressure (by 3-6 mm Hg) was observed only after 9 months of ovidon administration and after 1 year of non-ovlon administration. Contraceptive agents with reduced dosage of steroid components (rigevidon or triquilar) produced less pronounced increase in systolic or diastolic blood pressure (less than by 2-3 mm Hg). The changes in blood pressure after the use of ovidon and non-ovlon were more pronounced in women with combined rank of risk factors of 7.