Abstract
Two new bicyclic lactones, myrotheciumones A (1) and B (2) which possessed a rare ring-fusion system were isolated from Myrothecium roridum (M. roridum), an endophytic fungus of the medicinal herb plant Ajuga decumbens (A. decumbens) via an in vitro cytotoxicity assay. Structures were deduced from 1D and 2D NMR (Nuclear magnetic resonance) data. Myrotheciumone A's in vitro cytotoxicity and apoptotic activity were evaluated and myrotheciumone A was shown to exert cytotoxicity via inducing apoptosis in cancer cell line.
Keywords:
Ajuga decumbens; Apoptosis; Cytotoxicity; Endophytic fungus; Myrotheciumones.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ajuga / microbiology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Ascomycota / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Bridged Bicyclo Compounds, Heterocyclic / isolation & purification
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Hep G2 Cells
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Humans
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology*
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Bridged Bicyclo Compounds, Heterocyclic
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Lactones
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myrotheciumone A