Individual telomere length decay in patients with spondyloarthritis

Mutat Res. 2014 Jul:765:1-5. doi: 10.1016/j.mrfmmm.2014.04.006. Epub 2014 Apr 24.

Abstract

Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.

Keywords: Ankylosing spondylitis; Psoriasis; Psoriatic arthritis; Telomere length; qPCR.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Humans
  • Leukocytes / metabolism*
  • Leukocytes / pathology
  • Male
  • Middle Aged
  • Polymerase Chain Reaction / methods
  • Psoriasis / genetics
  • Psoriasis / metabolism
  • Psoriasis / pathology
  • Spondylitis, Ankylosing / genetics
  • Spondylitis, Ankylosing / metabolism*
  • Spondylitis, Ankylosing / pathology
  • Telomere / genetics
  • Telomere / metabolism*
  • Telomere / pathology
  • Telomere Homeostasis*