Biological activities of new monohydroxylated brassinosteroid analogues with a carboxylic group in the side chain

Steroids. 2014 Jul:85:58-64. doi: 10.1016/j.steroids.2014.04.007. Epub 2014 Apr 21.

Abstract

Thirteen monohydroxylated brassinosteroids analogues were synthesized and tested for their biological activity in plant and animal systems. The cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard.

Keywords: Anticancer activity; Brassinosteroids; Molecular docking; Organic synthesis; Plant bioassays; Receptor kinase BRI1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brassinosteroids / administration & dosage
  • Brassinosteroids / chemical synthesis*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cholestanols / administration & dosage
  • Cholestanols / chemical synthesis*
  • Cytotoxins / administration & dosage
  • Cytotoxins / chemical synthesis*
  • Humans
  • Molecular Structure
  • Steroids, Heterocyclic / administration & dosage
  • Structure-Activity Relationship

Substances

  • Brassinosteroids
  • Cholestanols
  • Cytotoxins
  • Steroids, Heterocyclic
  • brassinolide