Mechanism and regulation of incisions during DNA interstrand cross-link repair

DNA Repair (Amst). 2014 Jul:19:135-42. doi: 10.1016/j.dnarep.2014.03.018. Epub 2014 Apr 24.

Abstract

A critical step in DNA interstrand cross-link repair is the programmed collapse of replication forks that have stalled at an ICL. This event is regulated by the Fanconi anemia pathway, which suppresses bone marrow failure and cancer. In this perspective, we focus on the structure of forks that have stalled at ICLs, how these structures might be incised by endonucleases, and how incision is regulated by the Fanconi anemia pathway.

Keywords: DNA interstrand crosslink repair; EME1; ERCC1; FAN1; FANCD2; FANCI; Fanconi anemia; MUS81; SLX1; SLX4; SNM1A; XPF.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA Damage / genetics*
  • DNA Repair / genetics*
  • DNA Replication / genetics*
  • DNA, Single-Stranded / genetics*
  • DNA, Single-Stranded / metabolism
  • Fanconi Anemia Complementation Group D2 Protein / genetics
  • Fanconi Anemia Complementation Group D2 Protein / metabolism
  • Humans
  • Recombinases / genetics
  • Recombinases / metabolism

Substances

  • DNA, Single-Stranded
  • FANCD2 protein, human
  • Fanconi Anemia Complementation Group D2 Protein
  • Recombinases