Beyond ubiquitination: proteolytic and nonproteolytic roles of HOS1

Jae-Hoon Jung; Hyo-Jun Lee; Mi-Jeong Park; Chung-Mo Park

doi:10.1016/j.tplants.2014.03.012

Beyond ubiquitination: proteolytic and nonproteolytic roles of HOS1

Trends Plant Sci. 2014 Aug;19(8):538-45. doi: 10.1016/j.tplants.2014.03.012. Epub 2014 Apr 22.

Authors

Jae-Hoon Jung¹, Hyo-Jun Lee², Mi-Jeong Park², Chung-Mo Park³

Affiliations

¹ Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK.
² Department of Chemistry, Seoul National University, Seoul 151-742, Korea.
³ Department of Chemistry, Seoul National University, Seoul 151-742, Korea; Plant Genomics and Breeding Institute, Seoul National University, Seoul 151-742, Korea. Electronic address: cmpark@snu.ac.kr.

PMID: 24768209
DOI: 10.1016/j.tplants.2014.03.012

Abstract

The E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1) functions as a cold signaling attenuator by degrading the INDUCER OF CBF EXPRESSION 1 transcription factor, which is a key regulator of the cold-induced transcriptome and freezing tolerance in plants. Recent studies demonstrate that HOS1 also plays nonproteolytic roles in gene expression regulation. HOS1 acts as a chromatin remodeling factor that modulates FLOWERING LOCUS C chromatin in cold regulation of flowering time. It associates with the nuclear pore complex to facilitate nucleocytoplasmic mRNA export to maintain circadian periodicity over a range of light and temperature conditions. In this review, we summarize recent advances in molecular mechanisms underlying HOS1 function during plant development in response to fluctuating environmental conditions.

Keywords: E3 ubiquitin ligase; HOS1; chromatin remodeling; circadian clock; mRNA export; photoperiodic flowering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cold Temperature
Photoperiod
Plant Proteins / metabolism*
Plant Stomata / growth & development
Proteolysis*
Ubiquitination*

Substances

Plant Proteins