Dependence on the CCR5 coreceptor for viral replication explains the lack of rebound of CXCR4-predicted HIV variants in the Berlin patient

Clin Infect Dis. 2014 Aug 15;59(4):596-600. doi: 10.1093/cid/ciu284. Epub 2014 Apr 23.

Abstract

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.

Keywords: Berlin-Patient; HIV; coreceptor; cure; stem cell transplantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • HIV Infections / therapy
  • HIV Infections / virology*
  • HIV-1 / physiology*
  • Humans
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / therapy*
  • Receptors, CCR5 / metabolism*
  • Receptors, CXCR4 / metabolism
  • Receptors, HIV / metabolism*
  • Stem Cell Transplantation*
  • Treatment Outcome
  • Viral Tropism*
  • Virus Replication

Substances

  • CCR5 protein, human
  • CXCR4 protein, human
  • Receptors, CCR5
  • Receptors, CXCR4
  • Receptors, HIV