Interpreting the conductance blockades of DNA translocations through solid-state nanopores

ACS Nano. 2014 May 27;8(5):4754-60. doi: 10.1021/nn501694n. Epub 2014 Apr 25.

Abstract

Solid-state nanopore electrical signatures can be convoluted and are thus challenging to interpret. In order to better understand the origin of these conductance changes, we investigate the translocation of DNA through small, thin pores over a range of voltage. We observe multiple, discrete populations of conductance blockades that vary with applied voltage. To describe our observations, we develop a simple model that is applicable to solid-state nanopores generally. These results represent an important step toward understanding the dynamics of the electrokinetic translocation process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • Electric Conductivity
  • Electrochemistry / methods*
  • Ions
  • Kinetics
  • Materials Testing
  • Models, Statistical
  • Nanopores*
  • Nanotechnology / methods*
  • Silicon / chemistry
  • Thermodynamics

Substances

  • Ions
  • DNA
  • Silicon