Molecular characterization of Cryptosporidium spp. in children from Mexico

PLoS One. 2014 Apr 22;9(4):e96128. doi: 10.1371/journal.pone.0096128. eCollection 2014.

Abstract

Cryptosporidiosis is a parasitic disease caused by Cryptosporidium spp. In immunocompetent individuals, it usually causes an acute and self-limited diarrhea; in infants, infection with Cryptosporidium spp. can cause malnutrition and growth retardation, and declined cognitive ability. In this study, we described for the first time the distribution of C. parvum and C. hominis subtypes in 12 children in Mexico by sequence characterization of the 60-kDa glycoprotein (GP60) gene of Cryptosporidium. Altogether, 7 subtypes belonging to 4 subtype families of C. hominis (Ia, Ib, Id and Ie) and 1 subtype family of C. parvum (IIa) were detected, including IaA14R3, IaA15R3, IbA10G2, IdA17, IeA11G3T3, IIaA15G2R1 and IIaA16G1R1. The frequency of the subtype families and subtypes in the samples analyzed in this study differed from what was observed in other countries.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Cryptosporidiosis / parasitology*
  • Cryptosporidium / classification
  • Cryptosporidium / genetics*
  • Feces / parasitology
  • Female
  • Genes, Protozoan
  • Glycoproteins / genetics*
  • Humans
  • Infant
  • Male
  • Mexico
  • Molecular Typing
  • Protozoan Proteins / genetics*
  • Sequence Analysis, DNA

Substances

  • Glycoproteins
  • Protozoan Proteins

Grants and funding

This work has been funded by University of Sonora funds and the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.