Abstract
In this paper we report the design, synthesis and evaluation of a series of seleno-dihydropyrimidinones as potential multi-targeted therapeutics for Alzheimer's disease. The compounds show excellent results as acetylcholinesterase inhibitors, being as active as the standard drug. All these compounds also show very good antioxidant activity through different mechanisms of action.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / drug therapy*
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Antioxidants / pharmacology
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Cholinesterase Inhibitors / pharmacology
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Drug Design*
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Humans
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Molecular Targeted Therapy*
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Pyrimidinones / chemical synthesis*
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Pyrimidinones / chemistry
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Pyrimidinones / pharmacokinetics
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Pyrimidinones / therapeutic use*
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Selenium / therapeutic use*
Substances
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Antioxidants
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Cholinesterase Inhibitors
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Pyrimidinones
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Selenium