The antibacterial properties of sulfur containing flavonoids

Lucian G Bahrin; Mircea O Apostu; Lucian M Birsa; Marius Stefan

doi:10.1016/j.bmcl.2014.03.071

The antibacterial properties of sulfur containing flavonoids

Bioorg Med Chem Lett. 2014 May 15;24(10):2315-8. doi: 10.1016/j.bmcl.2014.03.071. Epub 2014 Apr 2.

Authors

Lucian G Bahrin¹, Mircea O Apostu¹, Lucian M Birsa², Marius Stefan³

Affiliations

¹ Department of Chemistry, Al.I. Cuza University of Iasi, 11 Carol I, 700506 Iasi, Romania.
² Department of Chemistry, Al.I. Cuza University of Iasi, 11 Carol I, 700506 Iasi, Romania. Electronic address: lbirsa@uaic.ro.
³ Department of Biology, Al.I. Cuza University of Iasi, 11 Carol I, 700506 Iasi, Romania. Electronic address: stefanm@uaic.ro.

PMID: 24751444
DOI: 10.1016/j.bmcl.2014.03.071

Abstract

Some dithiocarbamic esters bearing a flavanone backbone, as well as their corresponding 1,3-dithiolium salts were tested against Staphylococcus aureus and Escherichia coli. The 1,3-dithiolium tricyclic flavonoids display good inhibitory properties against both Gram-positive and Gram-negative pathogens.

Keywords: Antibacterial activity; Dithiocarbamates; Dithiolium salts; Flavonoids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Escherichia coli / drug effects
Flavonoids / pharmacology*
Microbial Sensitivity Tests
Staphylococcus aureus / drug effects
Sulfur Compounds / pharmacology*

Substances

Anti-Bacterial Agents
Flavonoids
Sulfur Compounds