Biopolymer-based supramolecular micelles from β-cyclodextrin and methylcellulose

Jiaojiao Du; Xin Guo; Jiaxing Tu; Longqiang Xiao; Xiangxiang Jia; Liqiong Liao; Lijian Liu

doi:10.1016/j.carbpol.2012.05.079

Biopolymer-based supramolecular micelles from β-cyclodextrin and methylcellulose

Carbohydr Polym. 2012 Sep 1;90(1):569-74. doi: 10.1016/j.carbpol.2012.05.079. Epub 2012 May 30.

Authors

Jiaojiao Du¹, Xin Guo, Jiaxing Tu, Longqiang Xiao, Xiangxiang Jia, Liqiong Liao, Lijian Liu

Affiliation

¹ Department of Polymer Science, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

PMID: 24751078
DOI: 10.1016/j.carbpol.2012.05.079

Abstract

Supramolecular polymer micelles (SMPMs) were constructed from natural and natural-derived polymers: β-cyclodextrin (β-CD)/maleic anhydride modified β-cyclodextrin (MAh-β-CD) and methylcellulose (MC) in aqueous solution by one-pot self-assembly procedure, in which, β-CD and MAh-β-CD inclusion complexes were used as the hydrophilic shell and the free MC as the core. The shapes of the SMPMs were regular spheres with diameters of 25±5 nm. The critical micelle concentrations, calculated from steady-state fluorescence emission spectra, were around 15.13 and 20.89 mg/L for MC/β-CD and MC/MAh-β-CD SMPMs, respectively. The in vitro drug release behaviors of the micelles were studied using prednisone acetate as a model drug, and the results showed that the MC/MAh-β-CD micelle had a drug-enrichment core and excellent drug released behaviors with a sustaining release time of 700 h.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biopolymers / chemistry*
Methylcellulose / chemistry*
Micelles*
X-Ray Diffraction / methods
beta-Cyclodextrins / chemistry*

Substances

Biopolymers
Micelles
beta-Cyclodextrins
Methylcellulose
betadex