Potential use of a megamolecular polysaccharide sacran as a hydrogel-based sustained release system

Chem Pharm Bull (Tokyo). 2014;62(7):636-41. doi: 10.1248/cpb.c14-00053. Epub 2014 Apr 16.

Abstract

A megamolecular polysaccharide sacran was newly extracted from cyanobacterium Aphanothece sacrum. Sacran has many preferable properties for transdermal application, e.g. a safe biomaterial, a high moisturizing effect, a formation of film and hydrogel. Additionally, it was recently discovered that sacran has an anti-inflammatory effect for atopic dermatitis model mice. In this study, in order to evaluate the feasibility of sacran-hydrogel as a novel sustained release system, we prepared a sacran-hydrogel containing 4-biphenyl acetic acid (BPAA, an acidic drug), prednisolone (PD, a neutral drug) or chlorpheniramine maleate (CPM, a basic drug), and performed the in vitro release studies. The sacran-hydrogel containing BPAA, PD or CPM provided a sustained release profile in accordance with a quasi-Fickian diffusion model. Furthermore, the release rate of drugs from sacran-hydrogels can be controlled by adjusting the concentration of aluminum chloride as a cross linker. These results suggest the potential use of sacran-hydrogel as a sustained release system for drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aluminum Chloride
  • Aluminum Compounds / chemistry
  • Biocompatible Materials / chemistry
  • Chlorides / chemistry
  • Chlorpheniramine / chemistry
  • Chlorpheniramine / metabolism
  • Cyanobacteria / metabolism
  • Delayed-Action Preparations / chemistry*
  • Delayed-Action Preparations / metabolism
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Hydrogen-Ion Concentration
  • Phenylacetates / chemistry
  • Phenylacetates / metabolism
  • Polysaccharides / chemistry*
  • Polysaccharides / metabolism
  • Prednisolone / chemistry
  • Prednisolone / metabolism

Substances

  • Aluminum Compounds
  • Biocompatible Materials
  • Chlorides
  • Delayed-Action Preparations
  • Phenylacetates
  • Polysaccharides
  • sacran
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Aluminum Chloride
  • Chlorpheniramine
  • biphenylylacetic acid
  • Prednisolone