Abstract
Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.
Keywords:
Oncology; Peptidomimetics; Pro-apoptotics; SPION nanoparticles; Smac mimetics.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Apoptosis Regulatory Proteins
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Biomimetic Materials / chemistry
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Biomimetic Materials / pharmacology
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Cell Line, Tumor
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Dextrans / chemistry*
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Dextrans / pharmacology*
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HeLa Cells
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Humans
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Intracellular Signaling Peptides and Proteins / chemistry*
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Magnetite Nanoparticles / chemistry*
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Mitochondrial Proteins / chemistry*
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Nanoparticles / administration & dosage
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Nanoparticles / chemistry
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Neoplasms / drug therapy
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Neoplasms / pathology
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Protein Binding
Substances
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Antineoplastic Agents
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Apoptosis Regulatory Proteins
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DIABLO protein, human
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Dextrans
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Intracellular Signaling Peptides and Proteins
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Magnetite Nanoparticles
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Mitochondrial Proteins
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ferumoxtran-10