SPION-Smac mimetic nano-conjugates: putative pro-apoptotic agents in oncology

Bioorg Med Chem Lett. 2014 May 15;24(10):2374-8. doi: 10.1016/j.bmcl.2014.03.048. Epub 2014 Mar 25.

Abstract

Non-covalent (NP-1/3) and covalent (NP-A-1/3) pro-apoptotic SPION-Smac mimetic nano-conjugates antitumor agents are reported. The solution synthesis of key Smac mimetics, their support onto SPIONs through non-covalent adsorption (NP-1/3) or APTES-mediated covalent binding (NP-A-1/3), the analytical characterization of SPION-Smac mimetic conjugates, their target affinity in cell-free assays, and their cytotoxicity against tumor cells are thoroughly described.

Keywords: Oncology; Peptidomimetics; Pro-apoptotics; SPION nanoparticles; Smac mimetics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects
  • Apoptosis Regulatory Proteins
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / pharmacology
  • Cell Line, Tumor
  • Dextrans / chemistry*
  • Dextrans / pharmacology*
  • HeLa Cells
  • Humans
  • Intracellular Signaling Peptides and Proteins / chemistry*
  • Magnetite Nanoparticles / chemistry*
  • Mitochondrial Proteins / chemistry*
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Protein Binding

Substances

  • Antineoplastic Agents
  • Apoptosis Regulatory Proteins
  • DIABLO protein, human
  • Dextrans
  • Intracellular Signaling Peptides and Proteins
  • Magnetite Nanoparticles
  • Mitochondrial Proteins
  • ferumoxtran-10