A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3

Nat Prod Res. 2014;28(14):1070-4. doi: 10.1080/14786419.2014.905935. Epub 2014 Apr 16.

Abstract

One new naphthalene derivative, 1,8-dihydroxynaphthol-1-O-α-l-rhamnopyranoside (1), together with one known α-dibenzopyrone, alternariol (2), and five xanthones (3-7) were isolated from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. All the isolated compounds (1-7) were established by comprehensive analysis of the spectral data, especially 1D and 2D NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 exhibited moderate COX-2 inhibition, with IC50 values of 12.2 μM.

Keywords: Arthrinium sp.; naphthalene glycoside; secondary metabolite; sponge.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ascomycota / chemistry*
  • Cyclooxygenase 2 Inhibitors / chemistry
  • Cyclooxygenase 2 Inhibitors / isolation & purification*
  • Cyclooxygenase 2 Inhibitors / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Inhibitory Concentration 50
  • Molecular Structure
  • Naphthols / chemistry
  • Naphthols / isolation & purification*
  • Naphthols / pharmacology
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / microbiology*
  • Xanthones / chemistry
  • Xanthones / isolation & purification*
  • Xanthones / pharmacology

Substances

  • 1,8-dihydroxynaphthol-1-O-alpha-rhamnopyranoside
  • Cyclooxygenase 2 Inhibitors
  • Glycosides
  • Naphthols
  • Xanthones