Metachronous benign ovarian tumors are not uncommon in children

Seppo Taskinen; Alda Urtane; Riitta Fagerholm; Jouko Lohi; Mervi Taskinen

doi:10.1016/j.jpedsurg.2013.09.019

Metachronous benign ovarian tumors are not uncommon in children

J Pediatr Surg. 2014 Apr;49(4):543-5. doi: 10.1016/j.jpedsurg.2013.09.019. Epub 2013 Oct 3.

Authors

Seppo Taskinen¹, Alda Urtane², Riitta Fagerholm², Jouko Lohi³, Mervi Taskinen⁴

Affiliations

¹ Department of Pediatric Surgery, Children's Hospital, University of Helsinki, Helsinki, Finland. Electronic address: seppo.taskinen@hus.fi.
² Department of Pediatric Surgery, Children's Hospital, University of Helsinki, Helsinki, Finland.
³ Department of Pathology, University of Helsinki, Helsinki, Finland.
⁴ Department of Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, University of Helsinki, Helsinki, Finland.

PMID: 24726109
DOI: 10.1016/j.jpedsurg.2013.09.019

Abstract

Purpose: To evaluate the risk for metachronous ovarian tumor in pediatric patients with mature ovarian teratoma.

Methods: During 1981-2011, 22 children underwent oophorectomy for mature teratoma at the median age of 11.4 (range 1.5-15.3) years. The patients were followed-up in median 4.4 (range 0.5-25.5) years.

Results: None of the patients had synchronous bilateral tumor at the time of primary operation, but during follow-up five patients (23%) got metachronous contralateral ovarian tumor. The contralateral tumor was observed in median 3.6 (range 1-8.8) years after the primary operation. According to Kaplan-Meier analysis the risk for contralateral tumor was 14% ± 8% (SE) within five years and 66% ± 26% (SE) within 10 years. In this series, the contralateral tumor was operated by ovary preserving surgery. Three of the metachronous tumors were mature teratomas and two were seromucinous infantile cystadenomas. One patient had a second teratoma recurrence 14 years after the first recurrence.

Conclusions: More than one fifth of the children with ovarian mature teratoma get metachronous benign tumor to the contralateral ovary. Therefore a yearly ultrasound follow-up is needed for these patients up to potential pregnancy to enable early diagnosis, ovary preserving surgery and maintenance of fertility in the case of metachronous tumor.

Keywords: Children; Contralateral tumor; Cystadenoma; Metachronous tumor; Teratoma.

Publication types

Evaluation Study

MeSH terms

Adolescent
Child
Child, Preschool
Cystadenoma, Mucinous / diagnosis*
Cystadenoma, Mucinous / surgery
Cystadenoma, Serous / diagnosis*
Cystadenoma, Serous / surgery
Early Detection of Cancer
Female
Follow-Up Studies
Humans
Infant
Neoplasms, Second Primary / diagnosis*
Neoplasms, Second Primary / surgery
Ovarian Neoplasms / diagnosis
Ovarian Neoplasms / surgery*
Ovariectomy*
Retrospective Studies
Teratoma / diagnosis
Teratoma / surgery*

Supplementary concepts

Teratoma, Ovarian