Endothelium plays an important role in regulation of the activity of inflammation and oxidative stress. Numerous studies have shown that physical training affects endothelial function. It is proven that regular physical activity reduces the seventy of inflammation and the risk of cardiovascular events. Changes observed in effect of physical activity include increase in production of nitric oxide (NO), a decrease of plaque volume, a decrease in vascular wall viscosity and an increase in diastolic coronary perfusion. It has been shown that exercise reduces cardiovascular risk in subjects with diabetes, metabolic syndrome, coronary heart disease and hypertension, as well as in healthy people. In above populations the benefits result from improved endothelial function. It has been proven that regular physical activity improves enzymatic antioxidant systems and the immune response. It is a result of the stimulating effect of muscle tissue micro-injuries and recruitment of various cell types of the inflammatory response and their migration deeper into the tissues. The biggest changes in the immune response are observed in prolonged aerobic exercise. Physical activity has a significant impact on endothelial function, intensity of inflammatory processes and exponents of oxidative stress. There is a need for further researches, in particular in order to determine the optimal model of training.