Acrodermatitis enteropathica is an uncommon disease caused by hereditary or acquired zinc deficiency. It is characterized by a triad of alopecia, diarrhea and acral and periorificial dermatitis. It is treated with Zinc supplementation. We report a 31-year-old indigent and drug addict female with a cutaneous-mucous syndrome characteristic of acrodermatitis enteropathica. She had a positive clinical evolution after Zinc supplementation.