Bariatric surgery decreased the serum level of an endotoxin-associated marker: lipopolysaccharide-binding protein

Po-Jen Yang; Wei-Jei Lee; Ping-Huei Tseng; Po-Huang Lee; Ming-Tsan Lin; Wei-Shiung Yang

doi:10.1016/j.soard.2014.02.022

Bariatric surgery decreased the serum level of an endotoxin-associated marker: lipopolysaccharide-binding protein

Surg Obes Relat Dis. 2014 Nov-Dec;10(6):1182-7. doi: 10.1016/j.soard.2014.02.022. Epub 2014 Feb 27.

Authors

Po-Jen Yang¹, Wei-Jei Lee², Ping-Huei Tseng³, Po-Huang Lee⁴, Ming-Tsan Lin⁵, Wei-Shiung Yang⁶

Affiliations

¹ Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Surgery, National Taiwan University Hospital Jin-Shan Branch, New Taipei City, Taiwan; Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
² Department of Surgery, Min-Sheng General Hospital, Taoyuan, Taiwan.
³ Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
⁴ Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
⁵ Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: linmt@ntu.edu.tw.
⁶ Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: wsyang@ntu.edu.tw.

PMID: 24713521
DOI: 10.1016/j.soard.2014.02.022

Abstract

Background: Recent studies have shown serum lipopolysaccharide binding protein (LBP) is associated with obesity and related metabolic disorder. Bariatric surgery can significantly reduce weight, but reports about the change of LBP after bariatric surgery are limited. We investigated LBP concentration and its associations with clinical variables.

Methods: We enrolled 178 obese patients receiving different bariatric surgeries and 38 normal weight individuals. Fasting blood samples were collected at baseline in all and 1 year after surgery in obese individuals. The serum LBP concentration was measured.

Results: The percentage of excess weight loss of mini-gastric bypass, Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric band were 72.0±20.0%, 65.5±23.0%, 67.2±18.4%, and 16.1±14.3%, respectively. Serum LBP levels were higher in the obese participants than in the normal weight participants (49.9±15.7 versus 25.2±7.5 μg/mL; P<.001) at baseline and significantly decreased to 35.1±22.6 μg/mL after bariatric surgery (P<.001) in the obese group. In the bariatric participants, after multivariate analyses, preoperative LBP and the change of LBP with surgery were independently associated only with high sensitive C-reactive protein (hs-CRP) (P<.001) and the change of hs-CRP (P = .012), respectively, while none of the postoperative variables was independently associated with LBP.

Conclusion: LBP is associated with body mass index and hs-CRP. Bariatric surgery significantly decreased the serum level of LBP. The relationship between LBP and hs-CRP disappeared after bariatric surgery.

Keywords: Bariatric surgery; LBP; Obesity; hs-CRP.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acute-Phase Proteins
Adult
Bariatric Surgery / methods*
Biomarkers / blood
Body Mass Index
C-Reactive Protein / metabolism*
Carrier Proteins / blood*
Cohort Studies
Female
Follow-Up Studies
Gastrectomy / methods
Gastric Bypass / methods
Gastroplasty / methods
Humans
Linear Models
Male
Membrane Glycoproteins / blood*
Middle Aged
Multivariate Analysis
Obesity, Morbid / blood*
Obesity, Morbid / epidemiology
Obesity, Morbid / surgery*
Postoperative Care / methods
Preoperative Care / methods
Prospective Studies
Treatment Outcome
Weight Loss

Substances

Acute-Phase Proteins
Biomarkers
Carrier Proteins
Membrane Glycoproteins
lipopolysaccharide-binding protein
C-Reactive Protein