Specific activity measurement of ⁶⁴Cu: a comparison of methods

Tara Mastren; James Guthrie; Paul Eisenbeis; Tom Voller; Efrem Mebrahtu; J David Robertson; Suzanne E Lapi

doi:10.1016/j.apradiso.2014.03.016

Specific activity measurement of ⁶⁴Cu: a comparison of methods

Appl Radiat Isot. 2014 Aug:90:117-21. doi: 10.1016/j.apradiso.2014.03.016. Epub 2014 Mar 20.

Authors

Tara Mastren¹, James Guthrie², Paul Eisenbeis³, Tom Voller³, Efrem Mebrahtu³, J David Robertson⁴, Suzanne E Lapi⁵

Affiliations

¹ Department of Chemistry, Washington University, 1 Brookings Drive, St Louis, MO 63130, USA.
² University of Missouri Research Reactor, 1513 Research Park Drive, Columbia, MO 65211, USA.
³ Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd, Campus Box 8225, St Louis, MO 63110, USA.
⁴ University of Missouri Research Reactor, 1513 Research Park Drive, Columbia, MO 65211, USA; Department of Chemistry, University of Missouri, 601 S. College Avenue, Columbia, MO 65211, USA.
⁵ Department of Chemistry, Washington University, 1 Brookings Drive, St Louis, MO 63130, USA; Department of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd, Campus Box 8225, St Louis, MO 63110, USA. Electronic address: lapis@mir.wustl.edu.

PMID: 24709610
DOI: 10.1016/j.apradiso.2014.03.016

Abstract

Effective specific activity of (64)Cu (amount of radioactivity per µmol metal) is important in order to determine purity of a particular (64)Cu lot and to assist in optimization of the purification process. Metal impurities can affect effective specific activity and therefore it is important to have a simple method that can measure trace amounts of metals. This work shows that ion chromatography (IC) yields similar results to ICP mass spectrometry for copper, nickel and iron contaminants in (64)Cu production solutions.

Keywords: Copper-64; Effective specific activity; Ion chromatography; Trace metal analysis.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.