New advances in CMV and immunosenescence

Paolo Sansoni; Rosanna Vescovini; Francesco F Fagnoni; Arne Akbar; Ramon Arens; Yen-Ling Chiu; Luka Cičin-Šain; Julie Dechanet-Merville; Evelyna Derhovanessian; Sara Ferrando-Martinez; Claudio Franceschi; Daniela Frasca; Tamas Fulöp; David Furman; Effrossyni Gkrania-Klotsas; Felicia Goodrum; Beatrix Grubeck-Loebenstein; Mikko Hurme; Florian Kern; Daniele Lilleri; Miguel López-Botet; Andrea B Maier; Thomas Marandu; Arnaud Marchant; Catharina Matheï; Paul Moss; Aura Muntasell; Ester B M Remmerswaal; Natalie E Riddell; Kathrin Rothe; Delphine Sauce; Eui-Cheol Shin; Amanda M Simanek; Megan J Smithey; Cecilia Söderberg-Nauclér; Rafael Solana; Paul G Thomas; Rene van Lier; Graham Pawelec; Janko Nikolich-Zugich

doi:10.1016/j.exger.2014.03.020

New advances in CMV and immunosenescence

Exp Gerontol. 2014 Jul:55:54-62. doi: 10.1016/j.exger.2014.03.020. Epub 2014 Apr 3.

Authors

Paolo Sansoni¹, Rosanna Vescovini², Francesco F Fagnoni³, Arne Akbar⁴, Ramon Arens⁵, Yen-Ling Chiu⁶, Luka Cičin-Šain⁷, Julie Dechanet-Merville⁸, Evelyna Derhovanessian⁹, Sara Ferrando-Martinez¹⁰, Claudio Franceschi¹¹, Daniela Frasca¹², Tamas Fulöp¹³, David Furman¹⁴, Effrossyni Gkrania-Klotsas¹⁵, Felicia Goodrum¹⁶, Beatrix Grubeck-Loebenstein¹⁷, Mikko Hurme¹⁸, Florian Kern¹⁹, Daniele Lilleri²⁰, Miguel López-Botet²¹, Andrea B Maier²², Thomas Marandu⁷, Arnaud Marchant²³, Catharina Matheï²⁴, Paul Moss²⁵, Aura Muntasell²¹, Ester B M Remmerswaal²⁶, Natalie E Riddell⁴, Kathrin Rothe²⁷, Delphine Sauce²⁸, Eui-Cheol Shin²⁹, Amanda M Simanek³⁰, Megan J Smithey¹⁶, Cecilia Söderberg-Nauclér³¹, Rafael Solana³², Paul G Thomas³³, Rene van Lier³⁴, Graham Pawelec⁹, Janko Nikolich-Zugich³⁵

Affiliations

¹ Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy. Electronic address: paolo.sansoni@unipr.it.
² Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
³ Immunohematology and Transfusion Center, Hospital of Parma, Parma, Italy.
⁴ Division of Infection and Immunity, University College London, London, United Kingdom.
⁵ Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.
⁶ Institute of Cell Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
⁷ Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
⁸ Composantes Innées de la Response Immunitaire et Différenciation, University of Bordeaux, Bordeaux, France.
⁹ Department of Internal Medicine II, Center for Medical Research University of Tübingen, Tübingen, Germany.
¹⁰ Laboratorio de InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón and Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
¹¹ Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
¹² Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA.
¹³ Division of Geriatrics and Research Center on Aging, Department of Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
¹⁴ Composantes Innées de la Response Immunitaire et Différenciation, University of Bordeaux, Bordeaux, France; Department of Microbiology & Immunology, School of Medicine, Stanford University, CA, USA.
¹⁵ Medical Research Council Epidemiology Unit, Cambridge, United Kingdom.
¹⁶ Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, USA.
¹⁷ Institute for Biomedical Aging Research, University of Innsbruck, Innsbruck, Austria.
¹⁸ Department of Microbiology and Immunology, University of Tampere, Tampere, Finland.
¹⁹ Division of Medicine, Pathogen Host Interaction (PHI), Brighton and Sussex Medical School, Brighton, United Kingdom.
²⁰ Laboratori Sperimentali di Ricerca, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
²¹ Immunology Unity, University Pompeu Fabra and Hospital del Mar Medical Research Institute, Barcelona, Spain.
²² Section of Gerontology and Geriatrics, Department of Internal Medicine, VU University Medical Center, Amsterdam, Netherlands.
²³ Institute for Medical Immunology, Université Libre de Bruxelles, Charleroi, Belgium.
²⁴ KU Leuven, Department of Public Health and Primary Care, Leuven, Belgium.
²⁵ School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom.
²⁶ Department of Experimental Immunology and Renal Transplant Unit, Department of Internal Medicine, Amsterdam, Netherlands.
²⁷ Section of Rheumatology, University of Leipzig, Leipzig, Germany.
²⁸ INSERM, Infections and Immunity, Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, Paris, France.
²⁹ Laboratory of Immunology and Infectious Diseases (LIID), Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
³⁰ Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
³¹ Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
³² Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain.
³³ Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
³⁴ Division of Research, Sanquin Blood Supply Foundation, Amsterdam, Netherlands.
³⁵ Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, USA. Electronic address: jnikolich@medadmin.arizona.edu.

PMID: 24703889
DOI: 10.1016/j.exger.2014.03.020

Abstract

Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

Keywords: Cytomegalovirus infection; Immune homeostasis; Immunosenescence; Pathologies of aging; Virus-host interaction.

Publication types

Congress
Research Support, Non-U.S. Gov't

MeSH terms

Aging / immunology*
Cytomegalovirus / immunology
Cytomegalovirus / physiology
Cytomegalovirus Infections / immunology*
Cytomegalovirus Infections / virology
Host-Pathogen Interactions / immunology
Humans
Virus Latency / immunology

Abstract

Publication types

MeSH terms

Grants and funding