Direct myocardial implantation of human embryonic stem cells in a dog model of Duchenne cardiomyopathy reveals poor cell survival in dystrophic tissue

W Habeler; B Ghaleh; I Barthelemy; A Plancheron; A Bizé; C Carlos-Sampedrano; V Chetboul; A Berdeaux; M Pucéat; M Peschanski; S Blot; C Monville

doi:10.46582/jsrm.0702013

Direct myocardial implantation of human embryonic stem cells in a dog model of Duchenne cardiomyopathy reveals poor cell survival in dystrophic tissue

J Stem Cells Regen Med. 2011 Oct 30;7(2):80-6. doi: 10.46582/jsrm.0702013. eCollection 2011.

Authors

W Habeler¹, B Ghaleh², I Barthelemy³, A Plancheron¹, A Bizé², C Carlos-Sampedrano², V Chetboul², A Berdeaux², M Pucéat⁴, M Peschanski⁵, S Blot³, C Monville⁵

Affiliations

¹ CECS, I-Stem, AFM , Evry 91030 cedex, France.
² INSERM, U955, Créteil , 94000, France ; Université Paris Est, Faculté de médecine, Créteil and Ecole Nationale Vétérinaire d'Alfort , 94000, France.
³ Université Paris Est, Ecole Nationale Vétérinaire d'Alfort, UPR de Neurobiologie , 94704 Maisons-Alfort, France.
⁴ INSERM U633, Avenir Program, Embryonic Stem Cells and Cardiogenesis , Evry, France.
⁵ INSERM U861, I-STEM, AFM , Evry 91030 cedex France ; UEVE U861, I-STEM, AFM , Evry 91030 cedex France.

Abstract

Duchenne muscular dystrophy is characterized by progressive muscle weakness and early death resulting from dystrophin deficiency. Spontaneous canine muscular disorders are interesting settings to evaluate the relevance of innovative therapies in human using pre-clinical trials.

Keywords: Duchenne Muscular Dystrophy; Golden Retriever Muscular Dystrophy; Human Embryonic Stem Cells; Transplantation.