Understanding tissue context influences on intratumour heterogeneity

Franziska Michor; Valerie M Weaver

doi:10.1038/ncb2942

Understanding tissue context influences on intratumour heterogeneity

Nat Cell Biol. 2014 Apr;16(4):301-2. doi: 10.1038/ncb2942.

Authors

Franziska Michor¹, Valerie M Weaver²

Affiliations

¹ Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02215, USA.
² Center for Bioengineering and Tissue Regeneration and Departments of Surgery, Anatomy, Bioengineering and Therapeutics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Helen Diller Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA.

PMID: 24691256
PMCID: PMC4180082
DOI: 10.1038/ncb2942

Abstract

Although human cancers exhibit intratumour heterogeneity, the influence of the tumour environment on this property is unclear. Single basal-like mammary epithelial cells are now shown to engage a dynamic TGFBR3-JUND signalling circuit in an extracellular-matrix-dependent manner. Cell transition between the distinct gene expression states underlying this circuit alters their properties and may modulate their propensity to malignancy.

Publication types

Comment

MeSH terms

Animals
Breast Neoplasms / metabolism*
Carcinoma, Intraductal, Noninfiltrating / metabolism*
Female
Humans
Keratin-5 / metabolism*
Proteoglycans / metabolism*
Proto-Oncogene Proteins c-jun / metabolism*
Receptors, Transforming Growth Factor beta / metabolism*

Substances

JunD protein, human
KRT5 protein, human
Keratin-5
Proteoglycans
Proto-Oncogene Proteins c-jun
Receptors, Transforming Growth Factor beta
betaglycan

Grants and funding

U54 CA143798/CA/NCI NIH HHS/United States