New cembranoids from the soft coral Sinularia arborea

Nat Prod Commun. 2014 Mar;9(3):361-2.

Abstract

From the ethyl acetate extract of the soft coral Sinularia arborea, a new cembrane-type diterpenoid, arbolide C (1), along with (+)-sarcophytol T (2), an enantiomer of the known cembrane, sarcophytol T, were isolated. The structures of compounds 1 and 2 were established by spectroscopic methods and 1 was found to display an inhibitory effect on the release of elastase by human neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Humans
  • Leukocyte Elastase / antagonists & inhibitors
  • Molecular Structure

Substances

  • Diterpenes
  • arbolide C
  • Leukocyte Elastase