Bio-inspired photonic-crystal microchip for fluorescent ultratrace detection

Abstract

Ultratrace detection attracts great interest because it is still a challenge to the early diagnosis and drug testing. Enriching the targets from highly diluted solutions to the sensitive area is a promising method. Inspired by the fog-collecting structure on Stenocara beetle's back, a photonic-crystal (PC) microchip with hydrophilic-hydrophobic micropattern was fabricated by inkjet printing. This device was used to realize high-sensitive ultratrace detection of fluorescence analytes and fluorophore-based assays. Coupled with the fluorescence enhancement effect of a PC, detection down to 10(-16) mol L(-1) was achieved. This design can be combined with biophotonic devices for the detection of drugs, diseases, and pollutions of the ecosystem.

Keywords: cocaine; enrichment; fluorescence enhancement; photonic crystals; ultratrace detection.