Cytomegalovirus in bone marrow cells correlates with cytomegalovirus in peripheral blood leukocytes

Angela Capobianchi; Anna Paola Iori; Alessandra Micozzi; Giovanni Fernando Torelli; Anna Maria Testi; Corrado Girmenia; Stefania Santilli; Walter Barberi; Guido Antonelli; Robin Foà; Giuseppe Gentile

doi:10.1128/JCM.00702-14

Cytomegalovirus in bone marrow cells correlates with cytomegalovirus in peripheral blood leukocytes

J Clin Microbiol. 2014 Jun;52(6):2183-5. doi: 10.1128/JCM.00702-14. Epub 2014 Mar 26.

Affiliations

¹ Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy.
² Department of Molecular Medicine, Sapienza University, Rome, Italy.
³ Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy gentile@bce.uniroma1.it.

Abstract

In allogeneic hematopoietic stem cell transplant recipients with bone marrow (BM) suppression, cytomegalovirus (CMV) pp65 antigenemia and DNA were detectable in peripheral blood leukocytes (PBL) and BM cells. A relationship between CMV infection of PBL and BM cells has been found.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Bone Marrow Cells / virology*
Child
Child, Preschool
Cytomegalovirus / isolation & purification*
Cytomegalovirus Infections / virology*
DNA, Viral / blood
Female
Humans
Leukocytes / virology*
Male
Middle Aged
Phosphoproteins / blood
Viral Matrix Proteins / blood
Young Adult

Substances

DNA, Viral
Phosphoproteins
Viral Matrix Proteins
pp67 protein, human cytomegalovirus