Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride

Acta Pharm. 2014 Mar;64(1):89-104. doi: 10.2478/acph-2014-0010.

Abstract

Eudragit E (EE)-sodium alginate (SA) polyelectrolyte complexes (PECs) were prepared at pH 4 and 5.8 using sodium alginate of high (SAH) and low viscosity (SAL). The optimum EE-SA complexation mass ratio was determined using viscosity measurements. Interactions between EE and SA in PECs were characterized by Fourier transform infra-red spectroscopy (FT-IR) and differential scanning calorimetry (DSC). Diltiazem hydrochloride (DTZ HCl) tablets were prepared using the prepared EE-SA PECs and their physical mixtures at different ratios as matrices. Tablets were evaluated for swelling characteristics and in vitro drug release. Tablets containing EE-SAH physical mixtures of ratios (1.5:1 and 1:3) as matrices were effective in achieving sustained release of DTZ HCl, where the percent drug released was significantly (p < 0.05) decreased compared to that from tablets either containing the same ratios of EE-SAL physical mixtures or the preformed EE- -SAH and EE-SAL PECs.

MeSH terms

  • Alginates / chemistry*
  • Diltiazem / chemistry*
  • Drug Carriers / chemistry*
  • Glucuronic Acid / chemistry
  • Hexuronic Acids / chemistry
  • Methylmethacrylates / chemistry*
  • Spectroscopy, Fourier Transform Infrared / methods

Substances

  • Alginates
  • Drug Carriers
  • Hexuronic Acids
  • Methylmethacrylates
  • Eudragit-E
  • Glucuronic Acid
  • Diltiazem