The role of surface functionality in nanoparticle exocytosis

Adv Healthc Mater. 2014 Aug;3(8):1200-1202. doi: 10.1002/adhm.201400001. Epub 2014 Mar 24.

Abstract

Getting out is just as important for nano-therapeutics as getting in. Exocytosis rates determine residency time in the cell, an important determinant for therapeutic efficacy and also for eventual clearance from the cell. In this study, it is shown that exocytosis efficiency is determined by surface functionality, providing a strategy for optimizing nanocarriers.

Keywords: exocytosis; gold nanoparticle; inductively coupled plasma mass spectrometry; surface functionality.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Drug Carriers / chemistry*
  • Exocytosis
  • Gold / chemistry
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • MCF-7 Cells
  • Metal Nanoparticles / chemistry
  • Microscopy, Electron, Transmission
  • Nanomedicine
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Surface Properties

Substances

  • Drug Carriers
  • Gold