Abstract
New quaternary ammonium salt-type compounds with lipophilic cholesterol and terpene moieties were synthesized. The compounds showed promising antibacterial and antimycobacterial activities. Those compounds containing the cholesterol moiety showed significant activity against Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus faecium. On the contrary, the antimycobacterial activity increased with the presence of the terpene unit in the molecule.
Keywords:
Antibacterial activity; Antifungal activity; Cholesterol; Terpenes; Tuberculostatics.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
MeSH terms
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology*
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Cholesterol / analogs & derivatives
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Cholesterol / chemical synthesis*
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Cholesterol / pharmacology*
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Drug Design
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Enterococcus faecium / drug effects
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Enterococcus faecium / growth & development
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Fungi / drug effects
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Fungi / growth & development
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium / drug effects
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Mycobacterium / growth & development
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Quaternary Ammonium Compounds / chemical synthesis*
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Quaternary Ammonium Compounds / pharmacology*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Staphylococcus epidermidis / drug effects
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Staphylococcus epidermidis / growth & development
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Structure-Activity Relationship
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Terpenes / pharmacology*
Substances
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Anti-Infective Agents
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Quaternary Ammonium Compounds
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Terpenes
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Cholesterol