Two new antibiotic pyridones produced by a marine fungus, Trichoderma sp. strain MF106

Mar Drugs. 2014 Mar 6;12(3):1208-19. doi: 10.3390/md12031208.

Abstract

Two unusual pyridones, trichodin A (1) and trichodin B (2), together with the known compound, pyridoxatin (3), were extracted from mycelia and culture broth of the marine fungus, Trichoderma sp. strain MF106 isolated from the Greenland Seas. The structures of the new compounds were characterized as an intramolecular cyclization of a pyridine basic backbone with a phenyl group. The structure and relative configuration of the new compounds were established by spectroscopic means. The new compound 1 and the known compound 3 showed antibiotic activities against the clinically relevant microorganism, Staphylococcus epidermidis, with IC₅₀ values of 24 μM and 4 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Atlantic Ocean
  • Bacteria / drug effects
  • Benzopyrans / isolation & purification
  • Benzopyrans / metabolism*
  • Benzopyrans / pharmacology*
  • Carbohydrate Sequence
  • Cell Line, Tumor
  • Culture Media
  • Cyclization
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Humans
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Scanning
  • Models, Molecular
  • Molecular Conformation
  • Molecular Sequence Data
  • Mycelium / metabolism
  • Pyridones / isolation & purification*
  • Pyridones / metabolism
  • Pyridones / pharmacology*
  • Seawater / microbiology
  • Staphylococcus epidermidis / drug effects
  • Trichoderma / chemistry
  • Trichoderma / metabolism*
  • Trichoderma / ultrastructure

Substances

  • Anti-Bacterial Agents
  • Benzopyrans
  • Culture Media
  • Pyridones
  • trichodin A