Abstract
A series of O- and N-prenyl secondary metabolites of insect, fungal, and plant origin have been evaluated for their topical anti-inflammatory activity using the Croton oil ear test in mice as a model of acute inflammation. Some of the tested compounds revealed an effect (ID50 = 0.31 divided by 0.56 micromol/cm2) comparable with that of the reference non-steroidal anti-inflammatory drug indomethacin (ID50 = 0.23 micromol/cm2).
MeSH terms
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Animals
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Anti-Inflammatory Agents / isolation & purification*
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Ascomycota / chemistry*
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Ascomycota / metabolism
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Male
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Mice
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Pentanes / isolation & purification*
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Rutaceae / chemistry*
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Rutaceae / metabolism
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Secondary Metabolism
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Tyrosine / analogs & derivatives*
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Tyrosine / isolation & purification
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ortho-Aminobenzoates / isolation & purification*
Substances
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Anti-Inflammatory Agents
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N-acetyl-O-isopentenyl-L-tyrosine
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N-isopentenylanthranilic acid geranyl ester
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Pentanes
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ortho-Aminobenzoates
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Tyrosine