Obesity and vitamin D deficiency: trends to promote a more proatherogenic cardiometabolic risk profile

Edita Stokić; Aleksandar Kupusinac; Dragana Tomić-Naglić; Branka Kovačev Zavišić; Milena Mitrović; Dragana Smiljenić; Sanja Soskić; Esma Isenović

doi:10.1177/0003319714528569

Obesity and vitamin D deficiency: trends to promote a more proatherogenic cardiometabolic risk profile

Angiology. 2015 Mar;66(3):237-43. doi: 10.1177/0003319714528569. Epub 2014 Mar 21.

Authors

Edita Stokić¹, Aleksandar Kupusinac², Dragana Tomić-Naglić³, Branka Kovačev Zavišić³, Milena Mitrović³, Dragana Smiljenić⁴, Sanja Soskić⁵, Esma Isenović⁵

Affiliations

¹ Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia edith@sezampro.rs.
² Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia.
³ Medical Faculty in Novi Sad, Clinical Center of Vojvodina, Novi Sad, Serbia.
⁴ Medical Faculty in Novi Sad, University of Novi Sad, Novi Sad, Serbia.
⁵ Laboratory for Molecular Genetics and Radiobiology, Institute of nuclear sciences "Vinca", University of Belgrade, Belgrade, Serbia.

PMID: 24658164
DOI: 10.1177/0003319714528569

Abstract

Vitamin D deficiency is associated with cardiometabolic risk factors (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese patients (body mass index [BMI]: 43.5 ± 9.2 kg/m(2)) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m(2)). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25(OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D levels were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L; P < .001). There was a negative correlation between vitamin D level and anthropometric indicators of obesity: BMI (r = -0.64; P < .001), waist circumference (r = -0.59; P < .001), and body fat percentage (r = -0.64; P < .001) as well as with fasting plasma insulin (r = -0.35; P < .001) and homeostasis model assessment of insulin resistance (r = -0.35; P < .001). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile.

Keywords: cardiometabolic risk; obesity; vitamin D deficiency.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adiposity
Adult
Atherosclerosis / diagnosis
Atherosclerosis / epidemiology*
Biomarkers / blood
Blood Glucose / analysis
Body Mass Index
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Insulin / blood
Insulin Resistance
Lipids / blood
Male
Metabolic Syndrome / blood
Metabolic Syndrome / diagnosis
Metabolic Syndrome / epidemiology*
Middle Aged
Obesity / diagnosis
Obesity / epidemiology*
Prevalence
Risk Factors
Serbia / epidemiology
Vitamin D / analogs & derivatives
Vitamin D / blood
Vitamin D Deficiency / blood
Vitamin D Deficiency / diagnosis
Vitamin D Deficiency / epidemiology*
Waist Circumference

Substances

Biomarkers
Blood Glucose
Insulin
Lipids
Vitamin D
25-hydroxyvitamin D