Innovative strategy with potential to increase hemodialysis efficiency and safety

Hsiao-Chien Chen; Hsiu-Chen Lin; Hsi-Hsien Chen; Fu-Der Mai; Yu-Chuan Liu; Chun-Mao Lin; Chun-Chao Chang; Hui-Yen Tsai; Chih-Ping Yang

doi:10.1038/srep04425

Innovative strategy with potential to increase hemodialysis efficiency and safety

Sci Rep. 2014 Mar 21:4:4425. doi: 10.1038/srep04425.

Authors

Hsiao-Chien Chen¹, Hsiu-Chen Lin², Hsi-Hsien Chen³, Fu-Der Mai⁴, Yu-Chuan Liu⁴, Chun-Mao Lin⁵, Chun-Chao Chang⁶, Hui-Yen Tsai⁵, Chih-Ping Yang⁷

Affiliations

¹ 1] Department of Biochemistry, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan [2].
² 1] Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan [2] Department of Laboratory Medicine, Taipei Medical University Hospital, No. 252, Wu-Hsing St., Taipei 11031, Taiwan [3].
³ 1] Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan [2] Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, No. 252, Wu-Hsing St., Taipei 11031, Taiwan.
⁴ 1] Department of Biochemistry, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan [2] Biomedical Mass Imaging Research Center, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan.
⁵ Department of Biochemistry, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan.
⁶ 1] Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan [2] Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, No. 252, Wu-Hsing St., Taipei 11031, Taiwan.
⁷ Graduate Institute of Medical Science, College of Medicine, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 11031, Taiwan.

Abstract

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10(-6) cm s(-1), by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blood Urea Nitrogen
Creatinine / blood
Creatinine / isolation & purification
Ferricyanides / chemistry
Gold / chemistry
Gold / pharmacology*
Hemodialysis Solutions / chemistry*
Hemodialysis Solutions / radiation effects
Humans
Light
Lipopolysaccharides / antagonists & inhibitors
Metal Nanoparticles / chemistry*
Nitric Oxide / antagonists & inhibitors
Oxidative Stress
Patient Safety
Renal Dialysis / methods*
Renal Insufficiency, Chronic / blood
Renal Insufficiency, Chronic / pathology
Renal Insufficiency, Chronic / therapy
Spectrum Analysis, Raman
Treatment Outcome

Substances

Ferricyanides
Hemodialysis Solutions
Lipopolysaccharides
Nitric Oxide
Gold
Creatinine
potassium ferricyanide