The aim of this study was to evaluate reliability and psychiatric clinical value of quantum resonance spectrometer (QRS) in detection of affective disorders. We studied 1014 patients with schizophrenia and 248 patients with mood disorders (including 93 patients with major depression). Affective disorder symptoms of the same subjects obtained from the QRS test and psychiatrists' diagnoses were compared. In addition, three affective disorder symptoms of renumbered 93 patients with major depression were discriminated using QRS. Kappa values of affective disorder detection and diagnosis were more than 0.69 in all three symptoms of schizophrenia and more than 0.65 in six of seven symptoms of mood disorder. The same consistency could also be seen in receiver operating characteristic curve area under the curve. In the discriminated analysis, sensitivity, specificity, positive predictive value, and negative predictive value of hypothymia, anxiety, and irritability detected using QRS are more than 0.66 compared with psychiatrists' diagnoses. QRS could be an objective identification and diagnosis instrument and might promote psychiatric clinical diagnosis.