Should we listen to warnings that linoleic acid (LA) promotes inflammation and that Americans would be healthier if they restricted their intake of LA (i.e., vegetable oils)? A recently published systematic review of 15 clinical trials failed to find any support for the "diet LA causes inflammation hypothesis." These findings support current recommendations that a diet with 5 to 10 energy percentage from polyunsaturated fatty acids, such as LA, is healthful and appropriate for most Americans.