A charge-switchable, four-armed polymeric photosensitizer for photodynamic cancer therapy

Chem Commun (Camb). 2014 Apr 28;50(33):4354-7. doi: 10.1039/c4cc00746h.

Abstract

A water-soluble, charge-switchable, four-armed polymeric photosensitizer (C4P-PS), in which charge switching is pH dependent, has been designed as a new class of photosensitizer for photodynamic cancer therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • HCT116 Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Lasers
  • Mice
  • Mice, Nude
  • Neoplasms / drug therapy
  • Photochemotherapy
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / pharmacology
  • Photosensitizing Agents / therapeutic use
  • Polymers / chemistry*
  • Porphyrins / chemistry*
  • Porphyrins / pharmacology
  • Porphyrins / therapeutic use
  • Transplantation, Heterologous
  • Water / chemistry

Substances

  • C4P-PS compound
  • Photosensitizing Agents
  • Polymers
  • Porphyrins
  • Water