8-Alkylcoumarins from the fruits of Cnidium monnieri protect against hydrogen peroxide induced oxidative stress damage

Chi-I Chang; Wan-Chiao Hu; Che-Piao Shen; Ban-Dar Hsu; Wei-Yong Lin; Ping-Jyun Sung; Wei-Hsien Wang; Jin-Bin Wu; Yueh-Hsiung Kuo

doi:10.3390/ijms15034608

8-Alkylcoumarins from the fruits of Cnidium monnieri protect against hydrogen peroxide induced oxidative stress damage

Int J Mol Sci. 2014 Mar 17;15(3):4608-18. doi: 10.3390/ijms15034608.

Authors

Chi-I Chang¹, Wan-Chiao Hu², Che-Piao Shen³, Ban-Dar Hsu⁴, Wei-Yong Lin⁵, Ping-Jyun Sung⁶, Wei-Hsien Wang⁷, Jin-Bin Wu⁸, Yueh-Hsiung Kuo⁹

Affiliations

¹ Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. changchii@mail.npust.edu.tw.
² Department of Chemistry, National Taiwan University, Taipei 106, Taiwan. r93223083@ntu.edu.tw.
³ Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan. d918214@oz.nthu.edu.tw.
⁴ Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 300, Taiwan. bdhsu@life.nthu.edu.tw.
⁵ Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan. linwy@mail.cmu.edu.tw.
⁶ Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. whw@mail.nsysu.edu.tw.
⁷ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. whw@mail.nsysu.edu.tw.
⁸ Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung 404, Taiwan. jbwu@mail.cmu.edu.tw.
⁹ Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. kuoyh@mail.cmu.edu.tw.

Abstract

Three new 8-alkylcoumarins, 7-O-methylphellodenol-B (1), 7-methoxy-8-(3-methyl- 2,3-epoxy-1-oxobutyl)chromen-2-one (2), and 3'-O-methylvaginol (3), together with seven known compounds (4-10) were isolated from the fruits of Cnidium monnieri. Their structures were determined by detailed analysis of spectroscopic data and comparison with the data of known analogues. All the isolates were evaluated the cytoprotective activity by MTS cell proliferation assay and the results showed that all the three new 8-alkylcoumarins exhibited cytoprotective effect on Neuro-2a neuroblastoma cells injured by hydrogen peroxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apiaceae / chemistry*
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Coumarins / chemistry
Coumarins / isolation & purification
Coumarins / pharmacology*
Fruit / chemistry*
Hydrogen Peroxide / toxicity*
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Neuroblastoma / pathology
Oxidants / toxicity
Oxidative Stress / drug effects*
Protective Agents / chemistry
Protective Agents / isolation & purification
Protective Agents / pharmacology

Substances

Coumarins
Oxidants
Protective Agents
coumarin
Hydrogen Peroxide