Diterpenes inhibiting NO production from Euphorbia helioscopia

Hongqiang Chen; Hao Wang; Bo Yang; Da-Qing Jin; Shuliang Yang; Meicheng Wang; Jing Xu; Yasushi Ohizumi; Yuanqiang Guo

doi:10.1016/j.fitote.2014.03.010

Diterpenes inhibiting NO production from Euphorbia helioscopia

Fitoterapia. 2014 Jun:95:133-8. doi: 10.1016/j.fitote.2014.03.010. Epub 2014 Mar 16.

Authors

Hongqiang Chen¹, Hao Wang², Bo Yang³, Da-Qing Jin⁴, Shuliang Yang³, Meicheng Wang², Jing Xu⁵, Yasushi Ohizumi⁶, Yuanqiang Guo⁷

Affiliations

¹ College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China; College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
² College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
³ College of Pharmacy, Harbin University of Commerce, Harbin 150076, China.
⁴ School of Medicine, Nankai University, Tianjin 300071, China.
⁵ College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China. Electronic address: xujing611@nankai.edu.cn.
⁶ Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
⁷ College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China. Electronic address: victgyq@nankai.edu.cn.

PMID: 24641945
DOI: 10.1016/j.fitote.2014.03.010

Abstract

Three new jatrophane diterpenes (1-3), an unreported spectroscopic data jatrophane diterpenene (4), and nine known analogues (5-13) have been isolated from the whole plants of Euphorbia helioscopia. Their structures were established by detailed spectroscopic data analyses (IR, ESIMS, HR-ESIMS, and 1D and 2D NMR), and the structure of 1 was confirmed by X-ray crystallography. The diterpenes showed inhibitory activities on LPS-induced NO production in murine microglial BV-2 cells.

Keywords: Diterpene; Euphorbia helioscopia; Inhibitory effects on NO production; Jatrophane diterpene.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line
Crystallography, X-Ray
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Euphorbia / chemistry*
Lipopolysaccharides / metabolism
Magnetic Resonance Spectroscopy
Medicine, Chinese Traditional
Mice
Microglia / drug effects
Molecular Structure
Nitric Oxide / metabolism*
Plant Extracts / chemistry
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
Plants, Medicinal

Substances

Diterpenes
Lipopolysaccharides
Plant Extracts
jatrophane
Nitric Oxide