A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view

Diagn Pathol. 2014 Mar 19:9:62. doi: 10.1186/1746-1596-9-62.

Abstract

Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease in a 39-yr-old male patient with fever and left axillary lymphadenitis. He had a history of cat bite on the left hand dorsum. On excision, the lymph node showed follicular hyperplasia, stellate microabscesses with a rim of granulomatous inflammation. Warthin-Starry silver staining showed many clumps of silver-stained bacilli within the necrotic foci. Serological tests were negative. Diagnosis was established by PCR analysis.

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Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Animals
  • Antibodies, Bacterial / blood*
  • Bartonella henselae / genetics
  • Bartonella henselae / immunology
  • Bartonella henselae / isolation & purification*
  • Biomarkers / blood
  • Biopsy
  • Cat-Scratch Disease / blood
  • Cat-Scratch Disease / diagnosis*
  • Cat-Scratch Disease / immunology
  • Cat-Scratch Disease / microbiology
  • Cat-Scratch Disease / transmission
  • Cats
  • DNA, Bacterial / isolation & purification
  • Humans
  • Lymph Nodes / immunology
  • Lymph Nodes / microbiology*
  • Lymph Nodes / pathology
  • Male
  • Polymerase Chain Reaction
  • Predictive Value of Tests
  • Serologic Tests*

Substances

  • Antibodies, Bacterial
  • Biomarkers
  • DNA, Bacterial