Antitumor activity of phenylene bridged binuclear bis(imino-quinolyl)palladium(II) and platinum(II) complexes

William M Motswainyana; Martin O Onani; Abram M Madiehe; Morounke Saibu

doi:10.1016/j.bmcl.2014.02.056

Antitumor activity of phenylene bridged binuclear bis(imino-quinolyl)palladium(II) and platinum(II) complexes

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1692-4. doi: 10.1016/j.bmcl.2014.02.056. Epub 2014 Feb 28.

Authors

William M Motswainyana¹, Martin O Onani², Abram M Madiehe³, Morounke Saibu³

Affiliations

¹ Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa. Electronic address: wmotswainyana@uwc.ac.za.
² Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.
³ Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa.

PMID: 24636106
DOI: 10.1016/j.bmcl.2014.02.056

Abstract

Antitumor effects of a known bis(imino-quinolyl)palladium(II) complex 1 and its newly synthesized platinum(II) analogue 2 were evaluated against human breast (MCF-7) and human colon (HT-29) cancer cell lines. The complexes gave cytotoxicity profiles that were better than the reference drug cisplatin. The highest cytotoxic activities were pronounced in complex 2 across the two examined cancer cell lines. Both compounds represent potential active drugs based on bimetallic complexes.

Keywords: Antitumor; Bis(imino-quinolyl); Cisplatin; Palladium(II); Platinum(II).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Benzene Derivatives / chemistry*
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HT29 Cells
Humans
MCF-7 Cells
Molecular Structure
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology*
Palladium / chemistry*
Platinum / chemistry*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Benzene Derivatives
Organometallic Compounds
Platinum
Palladium