Reductive amination without an external hydrogen Source

Denis Chusov; Benjamin List

doi:10.1002/anie.201400059

Reductive amination without an external hydrogen Source

Angew Chem Int Ed Engl. 2014 May 12;53(20):5199-201. doi: 10.1002/anie.201400059. Epub 2014 Mar 14.

Authors

Denis Chusov¹, Benjamin List

Affiliation

¹ A. N. Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences, Vavilova St. 28, Moscow (Russia). Denis.chusov@gmail.com.

PMID: 24634189
DOI: 10.1002/anie.201400059

Abstract

A method of reductive amination without an external hydrogen source is reported. Carbon monoxide is used as the reductant. The reaction proceeds efficiently for a variety of carbonyl compounds and amines at low catalyst loadings and is mechanistically interesting as it does not seem to involve molecular hydrogen.

Keywords: amination; amines; atom economy; carbon monoxide; reduction.