Characterization and biological activities of two copper(II) complexes with dipropylenetriamine and diamine as ligands

Mousa AL-Noaimi; Mohammad I Choudhary; Firas F Awwadi; Wamidh H Talib; Taibi Ben Hadda; Sammer Yousuf; Ashraf Sawafta; Ismail Warad

doi:10.1016/j.saa.2014.02.016

Characterization and biological activities of two copper(II) complexes with dipropylenetriamine and diamine as ligands

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jun 5:127:225-30. doi: 10.1016/j.saa.2014.02.016. Epub 2014 Feb 22.

Authors

Mousa AL-Noaimi¹, Mohammad I Choudhary², Firas F Awwadi³, Wamidh H Talib⁴, Taibi Ben Hadda⁵, Sammer Yousuf⁶, Ashraf Sawafta⁷, Ismail Warad⁸

Affiliations

¹ Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan. Electronic address: manoaimi@hu.edu.jo.
² Department of Chemistry, Science College, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
³ Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
⁴ Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, Jordan.
⁵ Laboratoire LCM, Faculty of Sciences, University Mohammed 1(ER), Oujda 60000, Morocco.
⁶ H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
⁷ Biology and Biotechnology Department, AN-Najah National University, P.O. Box 7, Nablus, Palestine.
⁸ Department of Chemistry, AN-Najah National University, P.O. Box 7, Nablus, Palestine.

PMID: 24632175
DOI: 10.1016/j.saa.2014.02.016

Abstract

Two new mixed-ligand copper(II) complexes, [Cu(dipn)(NN)]Br2(1-2) [dipn=dipropylenetriamine, NN=ethylenediamine (en) (1) and propylenediamine (pn) (2)], have been synthesized. These complexes were characterized by spectroscopic and thermal techniques. Crystal structure for 2 shows a distorted trigonal-bipyramidal geometry around Cu(II) ion with one solvate water molecule. Antimicrobial and antiproliferative assays were conducted to evaluate the biological activities of these complexes. The complexes exhibit a promising antimicrobial effect against an array of microbes at 200μg/mL concentration. The antiproliferative assay shows a high potential of these complexes to target Human keratinocyte cell line with IC50 values of 155 and 152μM. The absorption spectrum of 2 in water was modeled by time-dependent density functional theory (TD-DFT).

Keywords: Biological activity; Cu(II) complexes; Polyamine ligands; Single-crystal XRD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents* / chemistry
Anti-Infective Agents* / pharmacology
Bacteria / growth & development*
Cell Proliferation / drug effects*
Copper* / chemistry
Copper* / pharmacology
Crystallography, X-Ray
Diamines* / chemistry
Diamines* / pharmacology
Humans
Imines* / chemistry
Imines* / pharmacology
Keratinocytes / cytology
Keratinocytes / metabolism*
Molecular Structure

Substances

Anti-Infective Agents
Diamines
Imines
Copper