Dose-response effect of a novel functional fibre, PolyGlycopleX(®), PGX(®), on satiety

Vicky A Solah; Jennie C Brand-Miller; Fiona S Atkinson; Roland J Gahler; Veronica Kacinik; Michael R Lyon; Simon Wood

doi:10.1016/j.appet.2014.02.021

Dose-response effect of a novel functional fibre, PolyGlycopleX(®), PGX(®), on satiety

Appetite. 2014 Jun:77:72-6. doi: 10.1016/j.appet.2014.02.021. Epub 2014 Mar 13.

Authors

Vicky A Solah¹, Jennie C Brand-Miller², Fiona S Atkinson², Roland J Gahler³, Veronica Kacinik⁴, Michael R Lyon⁵, Simon Wood⁶

Affiliations

¹ School of Public Health, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia. Electronic address: v.solah@curtin.edu.au.
² Boden Institute of Obesity, Nutrition and Exercise and the School of Molecular Bioscience, University of Sydney, Sydney, NSW, 2006, Australia.
³ Factors Group R and D, Burnaby, BC, V3N 4S9, Canada.
⁴ Canadian Centre for Functional Medicine, Coquitlam, BC, V3K 6Y2, Canada.
⁵ Canadian Centre for Functional Medicine, Coquitlam, BC, V3K 6Y2, Canada; Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
⁶ School of Public Health, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia; Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada; InovoBiologic Inc., Calgary, AB, Y2N 4Y7, Canada.

PMID: 24631638
DOI: 10.1016/j.appet.2014.02.021

Abstract

The objective of this research was to determine the dose-response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX(®) (PGX(®)), [(α-D-glucurono-α-manno-β-D-manno-β-D-gluco), (α-Lgulurono-β-D mannurono), (β-D-gluco-β-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX(®), in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX(®) doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.

Keywords: Dose; Fibre; Satiety.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alginates / administration & dosage*
Alginates / pharmacology
Appetite
Area Under Curve
Blood Glucose / metabolism*
Dietary Fiber / administration & dosage*
Dietary Fiber / pharmacology
Dose-Response Relationship, Drug
Drug Combinations
Humans
Polysaccharides, Bacterial / administration & dosage*
Polysaccharides, Bacterial / pharmacology
Postprandial Period
Satiation / drug effects*
Young Adult

Substances

Alginates
Blood Glucose
Dietary Fiber
Drug Combinations
PolyGlycoplex
Polysaccharides, Bacterial