Abstract
Breast myofibroblastomas are rare benign mesenchymal tumors belonging to the group of stromal breast tumors composed of spindle-shaped cells and characterized by a broad morphologic spectrum. Among the different morphologic variants described, breast MFBs can show smooth muscle cell differentiation in very rare cases. In terms of the genetic abnormalities found in this type of tumor, a deletion of chromosome 13q14 was recently confirmed by FISH in some cases of mammary MFB. In this paper, we report an unusual case of MFB with smooth muscle differentiation showing a deletion of chromosome 13q14.
Keywords:
Breast; Myofibroblastoma; Smooth muscle differentiation.
Copyright © 2014 Elsevier GmbH. All rights reserved.
MeSH terms
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Aged
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics*
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Biopsy
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Breast Neoplasms / chemistry
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Breast Neoplasms / diagnosis*
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Breast Neoplasms / genetics
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Breast Neoplasms / pathology
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Breast Neoplasms / surgery
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Cell Differentiation*
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Chromosome Deletion
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Chromosome Disorders / diagnosis*
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Chromosome Disorders / genetics
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Chromosome Disorders / pathology
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Chromosomes, Human, Pair 13 / genetics
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Female
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Forkhead Box Protein O1
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Forkhead Transcription Factors / genetics*
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Gene Deletion*
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Genetic Predisposition to Disease
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Humans
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In Situ Hybridization, Fluorescence
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Myocytes, Smooth Muscle / chemistry
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Myocytes, Smooth Muscle / pathology*
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Neoplasms, Muscle Tissue / chemistry
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Neoplasms, Muscle Tissue / diagnosis*
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Neoplasms, Muscle Tissue / genetics
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Neoplasms, Muscle Tissue / pathology
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Neoplasms, Muscle Tissue / surgery
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Phenotype
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Predictive Value of Tests
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Ultrasonography, Mammary
Substances
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Biomarkers, Tumor
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FOXO1 protein, human
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Forkhead Box Protein O1
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Forkhead Transcription Factors