Rapid diagnosis of tuberculosis using ex vivo host biomarkers in sputum

Eur Respir J. 2014 Jul;44(1):254-7. doi: 10.1183/09031936.00209913. Epub 2014 Mar 13.

Affiliations

¹ Vaccinology Theme, Medical Research Council Unit, Fajara, the Gambia.
² DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Dept of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
³ Vaccinology Theme, Medical Research Council Unit, Fajara, the Gambia jsutherland@mrc.gm.

PMID: 24627540
DOI: 10.1183/09031936.00209913

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers / metabolism
Chemokine CCL2 / metabolism
Chemokine CXCL10 / metabolism
Communicable Disease Control
Cytokines / metabolism
Diagnostic Tests, Routine / instrumentation*
Diagnostic Tests, Routine / methods*
Epidermal Growth Factor / metabolism
Gambia
Humans
Reproducibility of Results
Sensitivity and Specificity
Sputum / metabolism*
Tuberculin / chemistry
Tuberculin Test
Tuberculosis / diagnosis*
Tuberculosis / metabolism*
Tumor Necrosis Factor-alpha / metabolism
Vascular Endothelial Growth Factor A / metabolism

Substances

Biomarkers
CCL2 protein, human
CXCL10 protein, human
Chemokine CCL2
Chemokine CXCL10
Cytokines
Tuberculin
Tumor Necrosis Factor-alpha
VEGFA protein, human
Vascular Endothelial Growth Factor A
Epidermal Growth Factor

Grants and funding