A facile approach to prepare a dual functionalized DNA based material in a bio-deep eutectic solvent

Chem Commun (Camb). 2014 Apr 18;50(30):3989-92. doi: 10.1039/c4cc00145a. Epub 2014 Mar 10.

Abstract

DNA (Salmon testes) was functionalized by Fe3O4 nanoparticles and protonated layered dititanate sheets (H2·Ti2O5·H2O) in a mixture of choline chloride and ethylene glycol (a deep eutectic solvent) to yield a hybrid material having magnetic and antibacterial properties. Ti sheets were found to interact with the phosphate moieties, while Fe interacted with the base pair of DNA in the hybrid material.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus subtilis / drug effects
  • Choline / chemistry*
  • DNA / chemistry*
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects
  • Ethylene Glycol / chemistry*
  • Magnetic Phenomena
  • Magnetite Nanoparticles / chemistry*
  • Microbial Sensitivity Tests
  • Particle Size
  • Pseudomonas fluorescens / drug effects
  • Shigella flexneri / drug effects
  • Solvents / chemistry
  • Structure-Activity Relationship
  • Surface Properties

Substances

  • Anti-Bacterial Agents
  • Magnetite Nanoparticles
  • Solvents
  • DNA
  • Ethylene Glycol
  • Choline