Long-lasting HHV-6 reactivation in long-term adult survivors after double umbilical cord blood allogeneic stem cell transplantation

J Infect Dis. 2014 Aug 15;210(4):567-70. doi: 10.1093/infdis/jiu129. Epub 2014 Mar 4.

Abstract

Higher incidence of human herpesvirus 6 (HHV-6) infection has been documented after umbilical cord blood allo-transplant in adults. Here we demonstrate that HHV-6 reactivation persists for a very long time in half of the patients after this type of graft. Long-term immune reconstitution does not explain this event, which remains to be explained.

Keywords: HHV-6; PBSC; adults; allo-SCT; cord blood; immune reconstitution.

MeSH terms

  • Adult
  • Aged
  • Female
  • Fetal Blood / transplantation
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Herpesviridae Infections / immunology*
  • Herpesvirus 6, Human / immunology
  • Herpesvirus 6, Human / physiology*
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Prospective Studies
  • Virus Activation / immunology*
  • Young Adult