RETRACTED: Probucol via inhibition of NHE1 attenuates LPS-accelerated atherosclerosis and promotes plaque stability in vivo

Exp Mol Pathol. 2014 Apr;96(2):250-6. doi: 10.1016/j.yexmp.2014.02.010. Epub 2014 Mar 1.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors. Concern had previously been raised about the veracity of some of the data in Figure 6 which appears to contain similar experimental data to many other publications, described here: https://pubpeer.com/publications/72ACDBE9751C8FD443A223FEB806E8#. The corresponding author contacted the journal and acknowledged that some of the experiments were not conducted by the authors themselves and they no longer have confidence in the reliability of the results. The authors would like to apologize for any inconvenience caused. The Editor-in-Chief agreed to retract the article.

Keywords: Atherosclerosis; Lipopolysaccharide; Na(+)/H(+) exchanger 1; Plaque stability; Probucol.

Publication types

  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Atherosclerosis / chemically induced
  • Atherosclerosis / drug therapy*
  • Atherosclerosis / metabolism
  • Calcium / metabolism
  • Calpain / administration & dosage
  • Cation Transport Proteins / biosynthesis*
  • Cation Transport Proteins / genetics
  • Humans
  • Lipopolysaccharides / toxicity
  • Mice
  • Plaque, Atherosclerotic / chemically induced
  • Plaque, Atherosclerotic / drug therapy*
  • Plaque, Atherosclerotic / metabolism
  • Probucol / administration & dosage
  • Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
  • Sodium-Hydrogen Exchanger 1
  • Sodium-Hydrogen Exchangers / biosynthesis*
  • Sodium-Hydrogen Exchangers / genetics

Substances

  • Cation Transport Proteins
  • Lipopolysaccharides
  • Proto-Oncogene Proteins c-bcl-2
  • SLC9A1 protein, human
  • Sodium-Hydrogen Exchanger 1
  • Sodium-Hydrogen Exchangers
  • Calpain
  • Probucol
  • Calcium