Gaining translational momentum: more zebrafish models for neuroscience research

Allan V Kalueff; David J Echevarria; Adam Michael Stewart

doi:10.1016/j.pnpbp.2014.01.022

Gaining translational momentum: more zebrafish models for neuroscience research

Prog Neuropsychopharmacol Biol Psychiatry. 2014 Dec 3:55:1-6. doi: 10.1016/j.pnpbp.2014.01.022. Epub 2014 Mar 1.

Authors

Allan V Kalueff¹, David J Echevarria², Adam Michael Stewart³

Affiliations

¹ ZENEREI Institute and Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA. Electronic address: avkalueff@gmail.com.
² Department of Psychology, University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA.
³ ZENEREI Institute and Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA; Department of Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA.

PMID: 24593944
DOI: 10.1016/j.pnpbp.2014.01.022

Abstract

Zebrafish (Danio rerio) are rapidly becoming a popular model organism in translational neuroscience and biological psychiatry research. Here we discuss conceptual, practical and other related aspects of using zebrafish in this field ("from tank to bedside"), and critically evaluate both advantages and limitations of zebrafish models of human brain disorders. We emphasize the need to more actively develop zebrafish models for neuroscience research focusing on complex traits.

Keywords: Animal models; Brain disorders; Translational neuroscience; Zebrafish.

Publication types

Introductory Journal Article

MeSH terms

Animals
Brain Diseases* / physiopathology
Disease Models, Animal*
Mental Disorders / physiopathology
Zebrafish* / physiology